Located along Puerto Rico’s scenic southern coast, Guayama is a vibrant city known for its colonial architecture, cultural landmarks, and easy coastal access. Nicknamed “La Ciudad Bruja” (The Witch City), Guayama enchants visitors with its picturesque Plaza Pública Cristóbal Colón and the striking Parroquia San Antonio de Padua, a 19th-century church anchoring the city’s historic center. The nearby Jobos Bay Reserve offers nature lovers a chance to explore protected wetlands and mangroves. Whether you’re visiting for a cultural deep dive or relaxing seaside escape, BookPuertoRico.com has handpicked the best hotels in Guayama to help you enjoy every moment of your stay.